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Home / Primary Antibodies

E2F-1 Polyclonal Antibody

SKU : BHA13715313

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Abbkine Scientific Co., Ltd.

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Mfr.No.	ABP0184
Alternative Names	E2F1 RBBP3
Background	The protein encoded by E2F1 (E2F transcription factor 1) is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Clonality	Polyclonal
Description	Rabbit Anti-E2F-1 Polyclonal Antibody
Formulation	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen, Liquid solution
Host	Rabbit
Immunogen	Synthetic peptide from human protein at AA range: 100-170
Immunogen Region	Synthetic peptide from human protein at AA range: 100-170
Isotype	Rabbit IgG
Molecular Weight	70 KD
Others	The antibody detects endogenous E2F-1 protein.
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Reactivity	Human, Mouse, Rat
Tag	E2F transcription factor 1
Note	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:50-1:200), IHC-P (1:50-1:300), ELISA (1:10000-1:20000). Not yet tested in other applications.

Accession Number	Q01094
Gene Id	1869, 1869

Concentration	1 mg/ml, 1 mg/ml
Purification	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen, The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
Storage Buffer	PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Storage Instructions	Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Applications	WB, IF, IHC-P, ELISA

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA13715313	ABP0184	100 uL	$229		Add to Cart

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