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Tyk2-KO

SKU : BHAM00349

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KO-201976
Description	Model Description: Exon 4 of Tyk2 gene was deleted to generate Tyk2 knockout mice. Official Symbol: Tyk2 NCBI ID: 54721 MGI ID: 1929470 Ensembl ID: ENSMUSG00000032175 Pubmed: Tyk2 Human Ortholog: TYK2
Nomenclature	C57BL/6JSmoc-Tyk2^em1Smoc
Exon	Exon 4
Disease	Obesity
Disease	Cardio-metabolic Disease
KI/KO Gene	Tyk2
Synonyms	JTK1

Reference	MGI:2654781 Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Larner AC, Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metab. 2012 Dec 5;16(6):814-24

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