Model Description: These mice carry loxP sites flanking exon 12-14 of Stat3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat3 gene.While Stat3-Flox(2)(Stock No.NM-CKO-200225)mice carrying the loxP sites flanking exon 18-20 of Stat3 gene.
Official Symbol: Stat3
NCBI ID: 20848
MGI ID: 103038
Ensembl ID: ENSMUSG00000004040
Pubmed: Stat3
Human Ortholog: STAT3
Nomenclature
C57BL/6JSmoc-Stat3tm7(flox)Smoc
Exon
Exon 12-14
Application
Cancer Research
Disease
Inflammatory Bowel Disease
Disease
Cardio-metabolic Disease
KI/KO Gene
Stat3
Notes
Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tek-cre mice.
Kano A, Wolfgang MJ, Gao Q, Jacoby J, Chai GX, Hansen W, Iwamoto Y, Pober JS, Flavell RA, Fu XY, Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med. 2003 Nov 17;198(10):1517-25