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Senp1-Flox

SKU : BHAM00295

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200277
Description	Model Description: These mice carry loxP sites flanking exon 4 of Senp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Senp1 gene. Official Symbol: Senp1 NCBI ID: 223870 MGI ID: 2445054 Ensembl ID: ENSMUSG00000033075 Pubmed: Senp1 Human Ortholog: SENP1
Nomenclature	C57BL/6JSmoc-Senp1^{em1(flox)Smoc}
Exon	Exon 4
Disease	Type 1 Diabetes Mellitus
Disease	Cardio-metabolic Disease
KI/KO Gene	Senp1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Fabp4-cre mice.
Synonyms	suPr-2, D15Ertd528e, 2310046A20Rik, E330036L07Rik

Reference	MGI:3618464 Shao L, Zhou HJ, Zhang H, Qin L, Hwa J, Yun Z, Ji W, Min W, SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nat Commun. 2015;6:8917

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