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Rrn3-Flox

SKU : BHAM00297

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Rrn3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Rrn3 gene. Official Symbol: Rrn3 NCBI ID: 106298 MGI ID: 1925255 Ensembl ID: ENSMUSG00000022682 Pubmed: Rrn3 Human Ortholog: RRN3
Nomenclature	C57BL/6JSmoc-Rrn3^{em1(flox)Smoc}
Exon	Exon s
Disease	Parkinson's Disease
Disease	Nervous System Disease
KI/KO Gene	Rrn3
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Slc6a3-icre mice.
Synonyms	Tif1a, R75565, TIF-1A, AL023001, E130302O19Rik

Reference	MGI:5688743 Rieker C, Engblom D, Kreiner G, Domanskyi A, Schober A, Stotz S, Neumann M, Yuan X, Grummt I, Schutz G, Parlato R, Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci. 2011 Jan 12;31(2):453-60

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