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Home / Animal Model / Disease Mice

R26-CAG-LSL-hSOD1*G94A-IRES-EGFP

SKU : BHAM00288

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KI-200263
Description	Model Description: A CAG-FRT-LSL- SOD1(G94A)-IRES-EGFP-WPRE-pA expression cassette was knocked into the Rosa26 locus. Official Symbol: Gt(ROSA)26Sor NCBI ID: 14910 MGI ID: 104735 Ensembl ID: ENSMUSG00000086429 Pubmed: Gt(ROSA)26Sor
Nomenclature	C57BL/6JSmoc-Gt(ROSA)26Sor^{em1(CAG-FRT-LSL- SOD1(G94A)-IRES-EGFP-WPRE-pA)Smoc}
Disease	Amyotrophic Lateral Sclerosis Type 1
KI/KO Gene	Gt(ROSA)26Sor
Notes	Note: The reference model was constructed by random transgene using the promoter of mouse thy1.2 gene and the mutant cDNA of human SOD1. NM-KI-200263 may require mating with Thy1-cre tool mice to obtain similar expected phenotypes.
Synonyms	R26,ROSA26,AV258896,Gtrgeo26,Gtrosa26,Thumpd3as1

Reference	Zhang B, et al., Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J Cell Biol. 1997 Dec 1;139(5):1307-15

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