Model Description: These mice carry loxP sites flanking exon 2 of Ptger4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ptger4 gene.
Official Symbol: Ptger4
NCBI ID: 19219
MGI ID: 104311
Ensembl ID: ENSMUSG00000039942
Pubmed: Ptger4
Human Ortholog: PTGER4
Nomenclature
C57BL/6JSmoc-Ptger4em1(flox)Smoc
Exon
Exon 2
Disease
Dilated Cardiomyopathy
Disease
Cardio-metabolic Disease
KI/KO Gene
Ptger4
Notes
Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myh6-cre mice.
Harding P, Yang XP, Yang J, Shesely E, He Q, LaPointe MC, Gene expression profiling of dilated cardiomyopathy in older male EP4 knockout mice. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H623-32