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Psen2-Flox

SKU : BHAM00241

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Psen2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Psen2 gene. Official Symbol: Psen2 NCBI ID: 19165 MGI ID: 109284 Ensembl ID: ENSMUSG00000010609 Pubmed: Psen2 Human Ortholog: PSEN2
Nomenclature	C57BL/6JSmoc-Psen2^{em1(flox)Smoc}
Exon	Exon s
Disease	Alzheimer's Disease
Disease	Nervous System Disease
KI/KO Gene	Psen2
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Psen1-Flox(NM-CKO-2101423) and Camk2a-cre mice.
Synonyms	PS2, Ad4h, Alg3, PS-2, STM2, ALG-3, Psnl2

Reference	MGI:3053798 Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ 3rd, Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease. Neuron. 2015 Mar 4;85(5):967-81

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