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Prkci-Flox

SKU : BHAM00247

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Prkci gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Prkci gene. Official Symbol: Prkci NCBI ID: 18759 MGI ID: 99260 Ensembl ID: ENSMUSG00000037643 Pubmed: Prkci Human Ortholog: PRKCI
Nomenclature	C57BL/6JSmoc-Prkci^{em1(flox)Smoc}
Exon	Exon s
Disease	Type 2 Diabetes Mellitus
Disease	Cardio-metabolic Disease
KI/KO Gene	Prkci
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ckmm-cre mice.
Synonyms	Pkci, Pkcl, Prkcl, AI427505, PKClambda, mKIAA4165, aPKClambda, 2310021H13Rik

Reference	MGI:2678248 Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR Jr, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M, Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest. 2007 Aug;117(8):2289-301

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