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Npc1-Flox

SKU : BHAM00208

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200070
Description	Model Description: These mice carry loxP sites flanking exon 9 of Npc1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Npc1 gene. Official Symbol: Npc1 NCBI ID: 18145 MGI ID: 1097712 Ensembl ID: ENSMUSG00000024413 Pubmed: Npc1 Human Ortholog: NPC1
Nomenclature	C57BL/6JSmoc-Npc1^{em2(flox)Smoc}
Exon	Exon 9
Application	Lipoprotein Metabolism And Metabolism Related Research
Disease	Niemann-Pick Disease
Disease	Rare Disease
KI/KO Gene	Npc1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with CAG-cre mice.
Synonyms	A430089E03Rik C85354 D18Ertd139e D18Ertd723e lcsd nmf164

Reference	A molecular mechanism explaining albuminuria in kidney disease. Nature Metabolism volume 2, pages461474 (2020) Yu T, Shakkottai VG, Chung C, Lieberman AP, Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration. Hum Mol Genet. 2011 Nov 15;20(22):4440-51

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