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Nf2-Flox

SKU : BHAM00193

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200017
Description	Model Description: These mice carry loxP sites flanking exon 2 of Nf2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nf2 gene. Official Symbol: Nf2 NCBI ID: 18016 MGI ID: 97307 Ensembl ID: ENSMUSG00000009073 Pubmed: Nf2 Human Ortholog: NF2
Nomenclature	C57BL/6JSmoc-Nf2^{tm1(flox)Smoc}
Exon	Exon 2
Application	Cancer Research
Disease	Renal Cell Carcinoma
Disease	Spontaneous Tumor
KI/KO Gene	Nf2
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Vil1-cre mice.
Synonyms	merlin

Reference	Morris ZS, McClatchey AI, Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9767-72

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