Model Description: These mice carry loxP sites flanking target exons of Myocd gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Myocd gene.
Official Symbol: Myocd
NCBI ID: 214384
MGI ID: 2137495
Ensembl ID: ENSMUSG00000020542
Pubmed: Myocd
Human Ortholog: MYOCD
Nomenclature
C57BL/6JSmoc-Myocdem1(flox)Smoc
Exon
Exon s
Disease
Patent Ductus Arteriosus
Disease
Cardio-metabolic Disease
KI/KO Gene
Myocd
Notes
Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pax3-cre mice.
Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS, Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest. 2008 Feb;118(2):515-25