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Med1-Flox

SKU : BHAM00190

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Med1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Med1 gene. Official Symbol: Med1 NCBI ID: 19014 MGI ID: 1100846 Ensembl ID: ENSMUSG00000018160 Pubmed: Med1 Human Ortholog: MED1
Nomenclature	C57BL/6JSmoc-Med1^{em1(flox)Smoc}
Exon	Exon s
Disease	Dilated Cardiomyopathy
Disease	Cardio-metabolic Disease
KI/KO Gene	Med1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myh6-cre mice.
Synonyms	PBP, Pparbp, TRIP-2, CRSP210, DRIP205, TRAP220, AI480703, l11Jus15

Reference	MGI:5007929 Jia Y, Chang HC, Schipma MJ, Liu J, Shete V, Liu N, Sato T, Thorp EB, Barger PM, Zhu YJ, Viswakarma N, Kanwar YS, Ardehali H, Thimmapaya B, Reddy JK, Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice. PLoS One. 2016;11(8):e0160755

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