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Mdm4-Flox

SKU : BHAM00172

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Mdm4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Mdm4 gene. Official Symbol: Mdm4 NCBI ID: 17248 MGI ID: 107934 Ensembl ID: ENSMUSG00000054387 Pubmed: Mdm4 Human Ortholog: MDM4
Nomenclature	C57BL/6JSmoc-Mdm4^{em1(flox)Smoc}
Exon	Exon s
Disease	Dilated Cardiomyopathy
Disease	Cardio-metabolic Disease
KI/KO Gene	Mdm4
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myh6-cre mice.
Synonyms	Mdmx, C85810, AA414968, AL023055, AU018793, AU021806, 4933417N07Rik

Reference	MGI:3624680 Xiong S, Van Pelt CS, Elizondo-Fraire AC, Fernandez-Garcia B, Lozano G, Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation. 2007 Jun 12;115(23):2925-30

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