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Madd-Flox

SKU : BHAM00179

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Madd gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Madd gene. Official Symbol: Madd NCBI ID: 228355 MGI ID: 2444672 Ensembl ID: ENSMUSG00000040687 Pubmed: Madd Human Ortholog: MADD
Nomenclature	C57BL/6JSmoc-Madd^{em1(flox)Smoc}
Exon	Exon s
Disease	Type 2 Diabetes Mellitus
Disease	Cardio-metabolic Disease
KI/KO Gene	Madd
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ins2-cre/ERT mice.
Synonyms	IG20, 9630059K23Rik

Reference	MGI:3582680 Li LC, Wang Y, Carr R, Haddad CS, Li Z, Qian L, Oberholzer J, Maker AV, Wang Q, Prabhakar BS, IG20/MADD plays a critical role in glucose-induced insulin secretion. Diabetes. 2014 May;63(5):1612-23

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