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Gck-Flox

SKU : BHAM00117

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Gck gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gck gene. Official Symbol: Gck NCBI ID: 103988 MGI ID: 1270854 Ensembl ID: ENSMUSG00000041798 Pubmed: Gck Human Ortholog: GCK
Nomenclature	C57BL/6JSmoc-Gck^{em1(flox)Smoc}
Exon	Exon s
Disease	Familial Hyperinsulinemic Hypoglycemia 3
Disease	Cardio-metabolic Disease
KI/KO Gene	Gck
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ins2-cre mice.
Synonyms	Gk, GLK, HK4, HKIV, HXKP, Hlb62, MODY2, Gls006

Reference	MGI:2681520 Tornovsky-Babeay S, Weinberg-Corem N, Ben-Haroush Schyr R, Avrahami D, Lavi J, Feleke E, Kaestner KH, Dor Y, Glaser B, Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes. Diabetologia. 2021 Feb 9;

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