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Gba-Flox

SKU : BHAM00120

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200051
Description	Model Description: These mice carry loxP sites flanking exon 8-11 of Gba gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gba gene.While Gba-Flox(2)(Stock No.NM-CKO-200179)mice carrying the loxP sites flanking exon 6-8 of Gba gene. Official Symbol: Gba NCBI ID: 14466 MGI ID: 95665 Ensembl ID: ENSMUSG00000028048 Pubmed: Gba Human Ortholog: GBA
Nomenclature	C57BL/6JSmoc-Gba^{em2(flox)Smoc}
Exon	Exon 8-11
Application	Gaucher Disease Research
Disease	Gaucher's Disease Type I
Disease	Rare Disease
KI/KO Gene	Gba
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tek-cre mice.
Synonyms	GC, GBA1, GLUC, GCase, betaGC

Reference	MGI:5293614 Sinclair GB, Jevon G, Colobong KE, Randall DR, Choy FY, Clarke LA, Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease. Mol Genet Metab. 2007 Feb;90(2):148-56

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