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Gadd45gip1-Flox

SKU : BHAM00103

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Gadd45gip1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gadd45gip1 gene. Official Symbol: Gadd45gip1 NCBI ID: 102060 MGI ID: 1914947 Ensembl ID: ENSMUSG00000033751 Pubmed: Gadd45gip1 Human Ortholog: GADD45GIP1
Nomenclature	C57BL/6JSmoc-Gadd45gip1^{em1(flox)Smoc}
Exon	Exon s
Disease	Type 2 Diabetes Mellitus
Disease	Cardio-metabolic Disease
KI/KO Gene	Gadd45gip1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ins2-cre mice.
Synonyms	Crif1, Plinp1, MRP-L59, AI425883, 2310040G17Rik

Reference	MGI:6191762 Kim YK, Joung KH, Ryu MJ, Kim SJ, Kim H, Chung HK, Lee MH, Lee SE, Choi MJ, Chang JY, Hong HJ, Kim KS, Lee SH, Kweon GR, Kim H, Lee CH, Kim HJ, Shong M, Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure. Diabetologia. 2015 Apr;58(4):771-80

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