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G6pc-Flox

SKU : BHAM00109

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200053
Description	Model Description: These mice carry loxP sites flanking exon 3 of G6pc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of G6pc gene. Official Symbol: G6pc NCBI ID: 14377 MGI ID: 95607 Ensembl ID: ENSMUSG00000078650 Pubmed: G6pc Human Ortholog: G6PC1
Nomenclature	C57BL/6JSmoc-G6pc^{em1(flox)Smoc}
Exon	Exon 3
Application	Diseases Associated With G6Pc Include Glycogen Storage Disease Ia And Hypoglycemia.
Disease	Glycogen Storage Disease I
Disease	Cardio-metabolic Disease, Rare Disease
KI/KO Gene	G6pc
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Kap-cre mice.
Synonyms	G6pt, G6Pase, AW107337, Glc-6-Pase

Reference	MGI:2677133 Clar J, Gri B, Calderaro J, Birling MC, Herault Y, Smit GP, Mithieux G, Rajas F, Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. Kidney Int. 2014 Oct;86(4):747-56

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