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F9-KO

SKU : BHAM00099

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KO-18046
Description	Model Description: The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.NM-KO-18046)carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.NM-KO-200607) carrying the exon 1-8 deletion. Official Symbol: F9 NCBI ID: 14071 MGI ID: 88384 Ensembl ID: ENSMUSG00000031138 Pubmed: F9 Human Ortholog: F9
Nomenclature	C57BL/6JSmoc-F9^em1Smoc
Exon	Exon 8
Application	Factor Ix (F9) Function And Gene Therapy
Disease	Hemophilia B
Disease	Rare Disease
KI/KO Gene	F9
Synonyms	Cf9 Cf-9

Reference	MGI:2175873 Wang L, Zoppe M, Hackeng TM, Griffin JH, Lee KF, Verma IM, A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11563-6

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