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Egln3-Flox

SKU : BHAM00087

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-2108727
Description	Model Description: These mice carry loxP sites flanking exon 2-3 of Egln3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Egln3 gene. Official Symbol: Egln3 NCBI ID: 112407 MGI ID: 1932288 Ensembl ID: ENSMUSG00000035105 Pubmed: Egln3 Human Ortholog: EGLN3
Nomenclature	C57BL/6JSmoc-Egln3^{em1(flox)Smoc}
Exon	Exon 2-3
Disease	cardiomyopathy
Disease	Cardio-metabolic Disease
KI/KO Gene	Egln3
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Egln1-Flox(NM-CKO-2100497) and Myh6-cre mice.
Synonyms	Phd3, SM-20, AI505553, AI648162, Hif-p4h-3, 2610021G09Rik

Reference	MGI:3610950 Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG Jr, Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation. 2010 Sep 7;122(10):1004-16

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