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Dicer1-Flox

SKU : BHAM00078

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200158
Description	Model Description: These mice carry loxP sites flanking exon 23 of Dicer1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dicer1 gene. Official Symbol: Dicer1 NCBI ID: 192119 MGI ID: 2177178 Ensembl ID: ENSMUSG00000041415 Pubmed: Dicer1 Human Ortholog: DICER1
Nomenclature	C57BL/6JSmoc-Dicer1^{em1(flox)Smoc}
Exon	Exon 23
Application	Hypoxia-Mediated Emt, Stem And Gene Expression Related Research
Disease	Ovarian Cancer
Disease	Cardio-metabolic Disease
KI/KO Gene	Dicer1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004)?P53-Flox(2)(NM-CKO-190067) and Amhr2-Cre mice.
Synonyms	D12Ertd7e, mKIAA0928, 1110006F08Rik

Reference	MGI:3623253 Kim J, Coffey DM, Ma L, Matzuk MM, The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice. Endocrinology. 2015 Jun;156(6):1975-81

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