Model Description: These mice carry loxP sites flanking target exons of Daam1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Daam1 gene.
Official Symbol: Daam1
NCBI ID: 208846
MGI ID: 1914596
Ensembl ID: ENSMUSG00000034574
Pubmed: Daam1
Human Ortholog: DAAM1
Nomenclature
C57BL/6JSmoc-Daam1em1(flox)Smoc
Exon
Exon s
Disease
Intrinsic Cardiomyopathy
Disease
Cardio-metabolic Disease
KI/KO Gene
Daam1
Notes
Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nkx2-5-Cre mice.
Ajima R, Bisson JA, Helt JC, Nakaya MA, Habas R, Tessarollo L, He X, Morrisey EE, Yamaguchi TP, Cohen ED, DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015 Dec 1;408(1):126-39