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Cdk4-KO

SKU : BHAM00044

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KO-190614
Description	Model Description: Exon 3-7 of Cdk4 gene was deleted to generate Cdk4 knockout mice. Official Symbol: Cdk4 NCBI ID: 12567 MGI ID: 88357 Ensembl ID: ENSMUSG00000006728 Pubmed: Cdk4 Human Ortholog: CDK4
Nomenclature	C57BL/6JSmoc-Cdk4^em1Smoc
Exon	Exon 3-7
Application	The Protein Encoded By This Gene Is A Member Of The Ser/Thr Protein Kinase Family.It Is A Catalytic Subunit Of The Protein Kinase Complex That Is Important For Cell Cycle G1 Phase Progression. The Activity Of This Kinase Is Restricted To The G1-S Phase, Which Is Controlled By The Regulatory Subunits D-Type Cyclins And Cdk Inhibitor P16(Ink4A). This Kinase Was Shown To Be Responsible For The Phosphorylation Of Retinoblastoma Gene Product (Rb).
Disease	Type 1 Diabetes Mellitus
Disease	Cardio-metabolic Disease
KI/KO Gene	Cdk4
Synonyms	Crk3

Reference	MGI:5301577 Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M, Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet. 1999 May;22(1):44-52

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