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Casp8-Flox

SKU : BHAM00047

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-190003
Description	Model Description: These Casp8 flox mice possess loxP sites flanking exons 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene. Official Symbol: Casp8 NCBI ID: 12370 MGI ID: 1261423 Ensembl ID: ENSMUSG00000026029 Pubmed: Casp8 Human Ortholog: CASP8
Nomenclature	C57BL/6JSmoc-Casp8^{em1(flox)Smoc}
Exon	Exon s
Application	Cancer Research,Apoptosis
Disease	Autoimmune Lymphoproliferative Syndrome Type 2B
Disease	Autoimmune Disease
KI/KO Gene	Casp8
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Lck-cre mice.
Synonyms	MACH, Mch5, FLICE, CASP-8

Reference	MGI:5014041 Salmena L, Hakem R, Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. J Exp Med. 2005 Sep 19;202(6):727-32

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