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Braf-Flox

SKU : BHAM00039

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200073
Description	Model Description: These mice carry loxP sites flanking exon 5 of Braf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Braf gene. Official Symbol: Braf NCBI ID: 109880 MGI ID: 88190 Ensembl ID: ENSMUSG00000002413 Pubmed: Braf Human Ortholog: BRAF
Nomenclature	C57BL/6JSmoc-Braf^{em1(flox)Smoc}
Exon	Exon 5
Application	Study On The Correlation Between Meiosis And Ret Signal Transduction In Oocytes
Disease	Melanoma
Disease	Rare Disease, Spontaneous Tumor
KI/KO Gene	Braf
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tyr-cre/ERT2 mice.
Synonyms	B-raf, Braf2, Braf-2, C87398, AA120551, AA387315, AA473386, C230098H17, D6Ertd631e, 9930012E13Rik

Reference	Dhomen N, Reis-Filho JS, da Rocha Dias S, Hayward R, Savage K, Delmas V, Larue L, Pritchard C, Marais R, Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell. 2009 Apr 7;15(4):294-303

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