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Bag3-Flox

SKU : BHAM00022

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-2101856
Description	Model Description: These mice carry loxP sites flanking exon 4 of Bag3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bag3 gene. Official Symbol: Bag3 NCBI ID: 29810 MGI ID: 1352493 Ensembl ID: ENSMUSG00000030847 Pubmed: Bag3 Human Ortholog: BAG3
Nomenclature	C57BL/6JSmoc-Bag3^{em1(flox)Smoc}
Exon	Exon 4
Disease	Dilated Cardiomyopathy 1Hh
Disease	Cardio-metabolic Disease
KI/KO Gene	Bag3
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myhca-cre mice.
Synonyms	Bis, mg638, AA407278

Reference	MGI:5829468 Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J, Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01;127(8):3189-3200

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BHAM00022	NM-CKO-2101856	-		Add to Quote

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