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Apoe-KO(2)

SKU : BHAM00011

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KO-190565
Description	Model Description: Apoe-KO(2) mice (Stock No.NM-KO-190565) carry a knockout allele derived from the targeted deletion of exon 2-4. While Apoe-KO mice (Stock No.NM-KO-00033) have been pulled from shelves for some reasons. Official Symbol: Apoe NCBI ID: 11816 MGI ID: 88057 Ensembl ID: ENSMUSG00000002985 Pubmed: Apoe Human Ortholog: APOE
Nomenclature	C57BL/6JSmoc-Apoe^em5Smoc
Exon	Exon 2-4.
Application	Atherosclerosis,Hyperlipidemia,Hypercholesterolemia,Cerebral Infarction,Ad,Chronic Hepatitis Etc.
Disease	Coronary Artery Disease
Disease	Cardio-metabolic Disease
KI/KO Gene	Apoe
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Scarb1-KO(NM-KO-201876) mice.
Synonyms	Apo-E, AI255918

Reference	MGI:3693216 Tsukamoto K, Mani DR, Shi J, Zhang S, Haagensen DE, Otsuka F, Guan J, Smith JD, Weng W, Liao R, Kolodgie FD, Virmani R, Krieger M, Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17023-8

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