This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
A portion of amino acids 255-282 from the human protein was used as the immunogen for this CYP1A2 antibody.
Isotype
Mouse IgG3
Species Reactivity
Human
Note
Titration of the CYP1A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
P05177
Format
Ascites
Purity
Ascites
Storage
Aliquot the CYP1A2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.