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Home / Proteins & Peptide

CXCL16, Mouse

SKU : BHP18500105

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iXCells Biotechnologies

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Mfr.No.	IX02853, IX02853-1, IX02853-25
Description	Mouse CXCL16 (CXC chemokine 16) is a nonELR motifcontaining CXC chemokine with a transmembrane domain. CX3CL1/Fractalkine and CXCL16 are the only two transmembrane chemokines within the superfamily. Mouse CXCL16 cDNA encodes a 246 amino acid (aa) precursor protein with a putative 26 aa residue signal peptide,an 88 aa residue chemokine domain, an 87 aa residue mucinlike spacer region, a 22 aa residue transmembrane domain, and a 23 aa residue cytoplasmic tail. Mouse and human CXCL16 share 49% overall aa identity and 70% similarity in the chemokine domains. Mouse CXCL16 is produced by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp both as membranebound and soluble forms. Based on northern blot analysis,CXCL16 is also expressed in some nonlymphoid tissues such as lung, small intestine and kidney. The receptor for CXCL16 has been identified as CXCR6/Bonzo (STRL33 and TYMSTR), a receptor previously shown to be a coreceptor for HIV entry.CXCR6 is expressed on naive CD8 cells, naturalkiller T cells and activated CD8 and CD4 T cells.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20°C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in PBS.
Molecular Weight	Approximately 9.9 kDa, a single non-glycosylated polypeptide chain containing 88 amino acids.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	Mouse
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Endotoxin Level	Less than 1 EU/ug of rMuCXCL16 as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine lymphocytes is in a concentration of 20-1000 ng/ml.

Synonyms	CXCL16, Mouse;
Sequence	NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCPFFIRFQLQSK SVCGGSQDQW?VRELVDCFER KECGTGHGKS FHHQKHLP

Purity	98 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500105-1	IX02853-1	1mg	$2621		Add to Cart
BHP18500105-2	IX02853-25	25ug	$199		Add to Cart

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