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Home / Primary Antibodies / IHC Antibodies

COPZ1 Antibody

SKU : BHA10559492

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA217102
Alternative Names	CGI-120; coatomer protein complex; subunit zeta 1; COPZ; zeta1-COP
Categories	Primary Antibodies
Clonality	polyclonal
Description	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.Futatsumori M., J. Biochem. 128:793-801(2000).Lai C.-H., Genome Res. 10:703-713(2000).Zhang Q.-H., Genome Res. 10:1546-1560(2000)
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human COPZ1.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. Futatsumori M., J. Biochem. 128:793-801(2000). Lai C.-H., Genome Res. 10:703-713(2000). Zhang Q.-H., Genome Res. 10:1546-1560(2000)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total COPZ1 protein.
Subcellular Location	Cytoplasm, Golgi apparatus membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasmic vesicle, COPI-coated vesicle membrane, Peripheral membrane protein, Cytoplasmic side

Uniprot	P61923
Database Links	HGNC:2243 OMIM:615472 KEGG:hsa:22818 STRING:9606.ENSP00000262061 UniGene:Hs.505652
Function	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Protein Families	Adaptor complexes small subunit family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559492	CSB-PA217102	100ul	$297		Add to Cart

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