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Home / Primary Antibodies / Conjugated Primary Antibodies

NOTCH3 Antibody, FITC conjugated

SKU : BHA10523570

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA892153LC01HU
Alternative Names	Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain], NOTCH3
Categories	Primary Antibodies
Clonality	polyclonal
Description	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Host	Rabbit
Immunogen	Recombinant Human Neurogenic locus notch homolog protein 3 protein (1301-1496AA)
Involvement In Disease	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, 1 (CADASIL1); Myofibromatosis, infantile 2 (IMF2); Lateral meningocele syndrome (LMNS)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Species	Homo Sapiens (Human)
Subcellular Location	Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Notch 3 intracellular domain: Nucleus

Uniprot	Q9UM47
Database Links	HGNC:7883 OMIM:125310 KEGG:hsa:4854 STRING:9606.ENSP00000263388 UniGene:Hs.8546
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Pathway	Notch signaling pathway Th1 and Th2 cell differentiation Apelin signaling pathway
Protein Families	NOTCH family
Research Area	Neuroscience
Tissue Specificity	Ubiquitously expressed in fetal and adult tissues.

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Applications	ELISA
Description	ELISA
Tested Application	ELISA

Datasheet
ELISA Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10523570	CSB-PA892153LC01HU	100ug	$299		Add to Cart
BHA10523570	CSB-PA892153LC01HU	50ug	$166		Add to Cart

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