Mycoplasma testing: The cell line has been screened using the MycoAlert Mycoplasma Detection kit (Lonza, #LT07-218) to confirm the absence of Mycoplasma species.
Host Species: hamster
Supplied as Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
Background
Trophoblast cell-surface antigen 2 (TROP-2), also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein that is highly expressed in a variety of solid cancers, yet has low expression in normal cells. Through a variety of signaling pathways, TROP2 regulates cancer growth and metastasis and is a favorable target for antibody drug conjugates (ADC) and immunotherapy.
Application
1. Useful for screening and validating antibodies against Trop2 and anti-Trop2 CAR-T for immunotherapy research and drug discovery. 2. Useful for Trop2 binding assays to screening for Trop2 ligands.
License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles.
Storage Stability
Cells will arrive upon dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.