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TLR9/ NF-kappaB Reporter - HEK293 Recombinant Cell Line

SKU : BHC18200063

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BPS Bioscience

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Mfr.No.	60685
Description	Recombinant HEK293 cell expressing firefly luciferase gene under the control of NF-kappaB response elements with constitutive expression of human TLR9 (Toll-like receptor 9, also been designated as CD289, a member of the toll-like receptor (TLR) family. GenBank Accession No. NM_017442) Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma-Aldrich #MP0025) to confirm the absence of Mycoplasma species. Host Species: human
Background	The family of Toll-like receptors (TLRs) acts as primary sensors that detect a wide variety of microbial components and elicit innate immune responses. Human TLR9 recognizes specific unmethylated CpG DNA motifs prevalent in microbial but not vertebrate genomic DNA, leading to innate and acquired immune responses. Stimulation of TLR9 triggers a signaling cascade leading to the activation of the transcription factor NF-kappaB, which controls the expression of an array of inflammatory cytokine genes.
Application	Screen for activators or inhibitors of TLR9 signaling in a cellular context and characterize the biological activity of TLR9 and its interactions with ligands
Host Cell	HEK293
Synonyms	TLR, TLR-9
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	Each vial contains ~2 x 10^6 cells in 1 ml of 10% DMSO
Storage Stability	Immediately upon receipt, store in liquid nitrogen.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200063	60685	2 vials	$1732.50		Add to Cart

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