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TCF/LEF reporter-HEK293 cell line (Wnt Signaling Pathway, Lithium-Dependent)

SKU : BHC18200013

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BPS Bioscience

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Mfr.No.	60501
Description	The Wnt Signaling Pathway TCF/LEF Reporter (Luc) - HEK293 Cell Line is designed for monitoring the activity of the Wnt/b-catenin signaling pathway. The Wnt Signaling Pathway TCF/LEF Reporter (Luc) - HEK293 Cell Line contains a firefly luciferase gene under the control of TCF/LEF responsive elements stably integrated into HEK293 cells. This cell line is validated for the response to the stimulation of mouse Wnt3a and to the treatment with an inhibitor of Wnt/b-catenin signaling pathway. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma Aldrich) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains ~1.5 X 10^6 cells in 1 ml of 10% DMSO.
Background	The Wnt pathway controls a large and diverse set of cell fate decisions in embryonic development, adult organ maintenance and disease. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to stabilization and nuclear translocation of beta-catenin. beta-catenin then binds to TCF/LEF transcription factors in the nucleus, leading to transcription and expression of Wnt-responsive genes.
Application	Monitor Wnt signaling pathway activity. Screen for activators or inhibitors of the Wnt/beta-catenin signaling pathway.
Biological Activity	This cell line is validated for the response to the stimulation of mouse Wnt3a and to the treatment of the inhibitor of Wnt/beta-catenin signaling pathway.
Host Cell	HEK293
Synonyms	WNT reporter, TCF cell line, LEF cell line, luciferase reporter
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	aqueous solution containing DMSO
Storage Stability	Store in liquid nitrogen immediately upon receipt.

Reference	1. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127(3):469-480. 2. Chen B et al. (2009) Small molecule-mediated disruption of Wnt-dependent signaling intissue regeneration and cancer. Nature Chemical Biology 5(2):100-107.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200013	60501	2 vials	$2755.50		Add to Cart

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