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STAT5 Reporter (Luc)- U937 Cell Line (GM-CSF)

SKU : BHC18200224

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BPS Bioscience

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Mfr.No.	79941
Description	The STAT5 Reporter (Luc)-U937 cell line is designed for monitoring STAT5 signal transduction pathway in the U937 cell line. It contains a firefly luciferase gene driven by the STAT5 response element located upstream of the minimal TATA promoter. After activation by GM-CSF, endogenous STAT5 binds to the DNA response elements, inducing transcription of the luciferase reporter gene. Mycoplasma testing: The cell line has been screened using the MycoAlert Mycoplasma Detection kit (Lonza, #LT07-218) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
Background	Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine stimulating the production of granulocytes and monocytes from bone marrow precursors. GM-CSF had pro-inflammatory functions and is a therapeutic target in autoimmune disease. GM-CSF signals through JAK2/STAT5 and stimulates the expression of STAT5 target genes.
Application	1. Screen for activators or inhibitors of the STAT5 signaling pathway. 2. Screen for the neutralization antibody of GM-CSF.
Host Cell	U937
Species	Human
Synonyms	Signal Transducer And Activator Of Transcription 5A cell line, MGF cells, U937 Reporter
Shipping Temperature	-80°C (dry ice)
Note	Visit Biohippobioscience.com/license for the label license and other key information about this product. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells will arrive upon dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200224	79941	2 vials	$2178		Add to Cart

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