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RARalpha Reporter - HEK293 Recombinant Cell Line

SKU : BHC18200014

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BPS Bioscience

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Mfr.No.	60503
Description	The RARalpha Reporter (Luc)-HEK293 Cell Line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARalpha (NM_000964). Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma Aldrich) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains ~2 X 10^6 cells in 1 ml of 10% DMSO.
Background	RAR belongs to a family of nuclear receptors and has three subtypes, RARalpha, RARbeta, and RARgamma. RAR heterodimerizes with RXR (retinoid X receptor) and acts as a transcription factor that regulates the growth and differentiation of both normal and malignant cells. When RAR binds to its ligands, all-trans retinoic acid or 9-cis retinoic acid, RAR/RXR heterodimer binds to retinoic acid response elements in the promoter region of target genes and recruits coactivator proteins, leading to transcription and expression of the downstream target genes.
Application	The RARalpha Reporter (Luc)-HEK293 Cell Line is designed for monitoring the activity of retinoic acid receptor alpha (RARalpha). Monitor RARalpha-regulated pathway activity Screen agonists or antagonists of RARalpha.
Biological Activity	This cell line is functionally validated for the response to the stimulation of all-trans retinoic acid. The expression of RARalpha is confirmed by Western blotting.
Host Cell	HEK293
Uniprot	P10276
Synonyms	RAR alpha, NCOR2, SMRT, RARA, Retinoic acid receptor alpha
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	aqueous solution containing DMSO
Storage Stability	Store in liquid nitrogen immediately upon receipt.

Reference	1. Petkovich, M, et al. Nature (1987) 330(6147): 444-450. 2. Allenby, G, et al. Proc. Natl. Acad. Sci. USA (1993) 90(1): 30-34.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200014	60503	2 vials	$2464		Add to Cart

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