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Home / Cells / Cell Lines

RANK / NF-kappaB Reporter - HEK293 Recombinant Cell Line

SKU : BHC18200083

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BPS Bioscience

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Mfr.No.	78102
Description	Recombinant HEK-293 cells expressing firefly luciferase gene under the control of Nuclear factor-kappaB (NF-kappaB) with constitMedium 1Gutive expression of human RANK (Receptor activator of nuclear factor-kappaB; TNFRSF11A; ref. seq. NM_003839.2). Mycoplasma testing: The cell line has been screened using the MycoAlert Mycoplasma Detection kit (Lonza, #LT07-218) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains ~2 x 10^6 cells in 1 ml of 10% DMSO.
Background	RANK/RANKL/OPG pathway plays a significant role in osteoclast maturation, which are the major cells in charge of bone resorption. If RANKL binds to the receptor RANK instead of binding to its decoy receptor Osteoprotegerin (OPG), it activates the NF-kappaB pathway to promote osteoclast survival and proliferation, resulting in the resorption of bone. Therefore, abnormal production of RANKL or OPG can cause osteoporosis and other bone-related disorders, making the RANKL/RANK signaling pathway a valuable target for drug development.
Application	Screen for inhibitors of RANKL/RANK signaling in a cellular context
Host Cell	HEK293
Species	Human
Synonyms	Receptor Activator Of NF-KB cell line, TNFRS11A cells, CD265 recombinant cell line
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells will arrive upon dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. Contact technical support at [email protected] if the cells are not frozen in dry ice upon arrival.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200083	78102	2 vials	$10340		Add to Cart

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