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PD-L1 /TCR activator - CHO Recombinant Cell line

SKU : BHC18200027

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BPS Bioscience

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Mfr.No.	60536
Description	Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143) an engineered T cell receptor (TCR) activator. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit(Sigma-Aldrich) to confirm the absence of Mycoplasma species. Host Species: hamster
Background	The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated Tcells,to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity andallows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involvedin regulating autoimmune responses, making these proteins promising therapeutic targets for anumber of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
Application	Screen for activators or inhibitors of PD-1 signaling in a cellular context , screen PD-L1 antibodies for binding affinity Characterize the biological activity of PD-1 interactions with PD-L1
Host Cell	CHO
Synonyms	Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Shipping Temperature	-80°C (dry ice)

Product Format	Aqueous solution containing DMSO
Storage Stability	Immediately upon receipt, store in liquid nitrogen.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200027	60536	2 vials	$12512.50		Add to Cart

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