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Home / Cells / Cell Lines

Myc Reporter (Luc) - HCT116 Cell Line (Myc Signaling Pathway)

SKU : BHC18200020

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BPS Bioscience

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Mfr.No.	60520
Description	The Myc Reporter - HCT116 cell line contains the firefly luciferase gene under the control of Myc responsive elements stably integrated into HCT116 cells, a human colon cancer cell line. HCT116 contains a mutated beta-catenin which leads to the accumulation of beta-catenin and constitutive activation of downstream Myc that induces the expression of Myc luciferase reporter. The cell line is validated for the inhibition of the expression of Myc luciferase reporter. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit(Sigma-Aldrich) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains 1.5 X 10^6 cells in 1 ml of 10% DMSO.
Background	The Myc signaling pathway plays an important role in cell proliferation, differentiation, transformation and apoptosis. The c-Myc protein is a transcription factor that heterodimerizeswith Max to regulate transcription of genes involved in proliferation, transformation andangiogenesis. Myc mutations have been linked to the development of a number of humancancers, including Burkitt's lymphoma, cervical, ovarian, breast, lung and pancreatic carcinoma,making Myc a promising therapeutic target.
Application	Monitor Myc pathway activity and screen for activators or inhibitors of the Myc pathway.
Host Cell	HCT116
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc.

Storage Stability	Immediately upon receipt, store in liquid nitrogen.

Reference	Pelengaris S, et al. (2002) c-MYC: more than just a matter of life and death. Nat. Rev.Cancer. 2(10): 764-76.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200020	60520	2 vials	$2392.50		Add to Cart

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