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IDO2 - HEK293 Recombinant Cell Line (Human)

SKU : BHC18200024

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BPS Bioscience

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Mfr.No.	60533
Description	Recombinant HEK293 cell line expressing tetracycline-inducible human indoleamine 2,3-dioxygenase (IDO2), Genbank accession number NM_194294. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma-Aldrich) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains ~1.5 X 10^6 cells in 1 ml of 10% DMSO
Background	L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells.The L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp. Additionally, the released degradation products of L-Trp have immunosuppressive functions. Indoleamine 2,3-dioxygenases (IDO1 & IDO2), two of the rate limiting enzymes in this pathway, are upregulated in many tumorsand provide cancer cells with an avenue for immune evasion.
Application	Monitor IDO2 pathway activity. Screen for activators or inhibitors of IDO2 in a cellular context.
Host Cell	HEK293
Species	Human
Synonyms	IDO2 Cell Line, IDO2, Indoleamine 2,3-dioxygenase 2, IDO, IDO2
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	Each vial contains ~1.5 X 10^6 cells in 1 ml of 10% DMSO
Storage Stability	Immediately upon receipt, store vials in liquid nitrogen.

Reference	1. Metz, R., et al., Int. Immunol. 2014; 26: 357-367. 2. Fatokun, A., et al., Amino Acids 2013; 45: 1319-1329.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200024	60533	2 vials	$11374		Add to Cart

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