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Home / Cells / Cell Lines

Growth Arrested PD-1 / NFAT Reporter - Jurkat Recombinant Cell Line

SKU : BHC18200202

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BPS Bioscience

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Mfr.No.	79687
Description	Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_005018). Note: These cells are unable to complete mitosis and are suitable for single use assays. For cells capable of reproducing, please use our PD-1 / NFAT Reporter - Jurkat Recombinant Cell Line, #60535. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma-Aldrich, #MP0025) to confirm the absence of Mycoplasma species. Host Species: human
Background	The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes. The cell cycle control system acts like a timer, or a clock, that sets a fixed amount of time for the cell to spend in each phase of the cell cycle. The four major phases of the mammalian cell cycle are G1, S, G2 and M phases. Cell-cycle arrest means the cell enters quiescent stage, where the cell becomes a permanent cell and is no longer active in the process of cell division.
Application	Screen for activators or inhibitors of PD-1 signaling in a cellular context. Characterize the biological activity of PD-1 and its interactions with ligands.
Host Cell	Jurkat
Synonyms	Programmed cell death 1, PDCD1, PD-1, PD1, SLEB2, CD279, HPD-L, PD1/NFAT, PD-1 NFAT, PD-1/NFAT
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit the use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	Each vial contains ~4 x 10^6 cells in 1 ml of FBS with 10% DMSO
Storage Stability	Immediately upon receipt, store in liquid nitrogen.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200202	79687	2 vials	$649		Add to Cart

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