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GR-GAL4 Reporter (Luc)-HEK293 Cell Line (Glucocorticoid Receptor Pathway)

SKU : BHC18200057

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BPS Bioscience

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Mfr.No.	60655
Description	The Glucocorticoid Receptor Pathway GAL4 Reporter (Luc) - HEK293 Cell Line contains afirefly luciferase gene under the control of glucocorticoid receptor ligand binding domain that isfused to the DNA binding domain (DBD) of GAL4 (GAL4 DBD-GR) stably integrated intoHEK293 cells. This fusion construct activates firefly luciferase expression under the control of amultimerized GAL4 upstream activation sequence (UAS). This allows for specific detection ofglucocorticoid-induced activation of the glucocorticoid receptor without the need for individualtranscriptional targets and with low cross-reactivity for other nuclear receptor pathways. This cellline is validated for response to stimulation of dexamethasone and to the treatment withmifepristone, an inhibitor of the glucocorticoid signaling pathway. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit(Sigma-Aldrich) to confirm the absence of Mycoplasma species. Host Species: human
Background	The glucocorticoid signaling pathway plays an important role in development, fluid homeostasis,cognition, immune response, and metabolism. Glucocorticoids are a class of steroid hormonesthat bind to the glucocorticoid receptor, causing it to translocate to the nucleus. Upontranslocation, the receptor can regulate the transcription of a large number of genes, includingthose that regulate glucose metabolism and inflammatory responses.
Application	Monitor glucocorticoid signaling pathway activity and screen activators or inhibitors of the glucocorticoid signaling pathway.
Biological Activity	This cell line is validated for the response to the stimulation of dexamethansone and to the treatment of the inhibitor mifepristone.
Host Cell	HEK293
Species	Human
Synonyms	GAL4, Glucocorticoid Receptor
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc.

Storage Stability	Immediately upon receipt, store in liquid nitrogen.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200057	60655	2 vials	$2502.50		Add to Cart

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