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BPS Bioscience
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BPS Bioscience
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| Mfr.No. | 78589 |
| Description | Recombinant HEK293 cells expressing the firefly luciferase gene under the control of cAMP response element (CRE), and with forced expression of human GIPR (Gastric Inhibitory Polypeptide receptor; NM_000164.4). Activation of GIPR in these cells can be monitored by measuring luciferase activity.The functionality of the GIPR/CRE Luciferase Reporter HEK293 Cell Line was validated in a dose-response assay using agonists gastric inhibitory peptide (GIP) and tirzepatide hydrochloride. These agonists induce luciferase activity in a dose-dependent manner as depicted in Figure 1.
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| Background | The gastric inhibitory polypeptide receptor (GIPR), also known as the glucose-dependent insulinotropic polypeptide receptor belongs to the Class B1 G protein-coupled receptor (GPCR) family. GIPR is primarily found in the β-cells of the pancreas and serves as a receptor for the gastric inhibitory polypeptide (GIP) hormone. As one of the incretin hormones, GIP modulates glucose metabolism by stimulating the pancreatic β-cells to release insulin. Since GIPR/GLP-1R heterodimerization has been shown to regulate GLP-1R signaling, dual agonists that bind both GIPR and GLP-1R have shown promising clinical efficacy for treating type II diabetes mellitus (T2DM) and obesity. |
| Application | Screen and characterize agonists of human GIPR in a cellular context |
| Host Cell | HEK293, Human Embryonic Kidney, epithelial-like cells, adherent |
| Uniprot | P48546 |
| Synonyms | Gastric inhibitory polypeptide receptor, GIP-R, Glucose-dependent insulinotropic polypeptide receptor, GIPR |
| Shipping Temperature | -80°C (dry ice) |
| Note | License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles |
