GAS(Luc) Report Cell Line-HeLa

Mfr.No.	ABC-RC099D
Description	The GAS reporter (Luc)-HeLa cell line is designed to monitor the activity of IFN gamma-induced signal transduction pathways in cultured cells by measuring activated STAT1 homodimers. It contains a firefly luciferase gene driven by three copies of the IFN gamma-activated sites (GAS) located upstream of the minimal TATA promoter. IFNy first binds to a heterodimeric receptor consisting of two chains, IFNGR1 and IFNGR2, causing its dimerization and the activation of specific Janus family kinases (JAK1 and JAK2). Two STAT1 molecules associate with this ligand-activated receptor complex and are activated by phosphorylation to form active homodimer. The active STAT1 homodimers translocate to the nucleus where they bind IFN gamma-activated sites (GAS) in the promoter of IFNy inducible genes, including luciferase reporter gene.
Categories	Transfected Stable Cell Lines
Application	For research use only
Host Cell	hela
Species	Human

Shipping	Dry Ice
Storage	Liquid Nitrogen

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