Recombinant RPMI 8226 cells constitutively expressing firefly (Photinus pyralis) luciferase (Biohippo #79834) have also been engineered to constitutively express the full length human FcRL5 (Fc Receptor Like 5, also known as CD307, ref. seq. NM_031281).
Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Host Species: human
Supplied as Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (Biohippo, #79796)
Background
FcRL5 is a single-pass type 1 membrane protein which contains 8 immunoglobulin-like C2-type domains. FcRL5 may be involved in B cell development and lymphomagenesis. Moreover, it is enriched in malignant plasma cells of patients diagnosed with multiple myeloma, and is an attractive target for antibody-drug conjugates (ADC) and anti-FcRL5 CAR T cells. RPMI 8226 cells are human B cells isolated from a plasmacytoma/myeloma patient.
Application
Use as target cells for anti-FcRL5 CAR T cells, anti-FcRL5 ADC, and bi-specific antibodies.
Host Cell
RPMI 8226
Uniprot
Q96RD9
Synonyms
Fc receptor-like protein 5, FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, FcRH5, Immune receptor translocation-associated protein 2, CD307e, IRTA2, UNQ503, PRO820
Shipping Temperature
-80°C (dry ice)
Note
License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/lentivirus-faq for detailed troubleshooting instructions. For all further questions, please email [email protected] Warning: Avoid freeze/thaw cycles.
Storage Stability
Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.