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FcGR3A (CD16A) CHO Cell Line

SKU : BHC18200107

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Mfr.No.	78332
Description	Recombinant CHO cell line stably expressing full length human CD16A (also known as FCGR3A, FcgammaRIIIa; ref. seq. NM_ 000569.8) under the control of the CMV promoter. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as Each vial contains 2 x 10⁶ cells in 1 ml of 10% DMSO
Background	Fc Gamma Receptor 3A (FcGRIIIA; FcgammaRIIIA), also known as CD16A, is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, antibody-dependent cytotoxicity, and clearance of immune complexes. The human FcGR3A displays a dimorphism at residue 158. One allele (V158) encodes a higher Fc affinity receptor variant with a valine at amino acid residue 158 while the other allele (F158) encodes a lower Fc affinity receptor variant having a phenylalanine at amino acid residue 158.FcGR3A (CD16A) plays a role in the activation of natural killer (NK) cells. Clinically, it serves as a marker of certain immune cells such as neutrophils. Its expression has been observed at the surface of T cells in patients with chronic viral infections (such as COVID-19). It is considered a potential therapeutic target to potentiate the efficacy of therapeutic antibodies used to treat solid tumors, or as direct target in hematopoietic cancers.
Application	Screen for antibodies binding to CD16A or examine CD16A function in a cellular context
Formulation	For best results, it is highly recommended to use these validated and optimized media from Biohippo. Other preparations or formulations of media may result in suboptimal performance. Thaw Medium 3 (Biohippo #60186): Ham's F-12 medium supplemented with 10% FBS, 1% Penicillin/StreptomycinGrowth Medium 3J (Biohippo #79974): Ham's F-12 medium supplemented with 10% FBS, 1% Penicillin/Streptomycin and 5 ug/ml Puromycin
Host Cell	CHO
Species	Human
Synonyms	Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, FcR-10, IgG Fc receptor III-2, CD_antigen: CD16a
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200107	78332	2 vials	$7865		Add to Cart

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