Recombinant clonal CHO cell line stably expressing full-length human claudin-9 (CLDN9 gene accession number NM_020982). Surface expression of claudin-9 was confirmed by flow cytometry. The stable clonal cell line was selected for high levels of claudin-9 expression compared to the parental CHO-K1 cell line.
Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species
Host Species: hamster
Supplied as Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (Biohippo #79796)
Background
Claudins are integral membrane proteins and major components of tight junction strands that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-9 is one of the 27 members of the Claudin family. Diseases associated with Claudin-9 include deafness, autosomal recessive 116, and Hepatitis C viral infection for which it acts as a co-receptor for viral entry
Application
Screen and validate antibodies against claudin-9 for drug discovery and research. Screen for compounds that regulate or inhibit claudin-9 signaling in a cellular context. Perform binding assays to screen for potential claudin-9 ligands.
Host Cell
CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Uniprot
O95484
Synonyms
CLDN9, DFNB116
Shipping Temperature
-80°C (dry ice)
Note
License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles
Storage Stability
Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.