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Claudin-18 Isoform 2 CHO Cell Line

SKU : BHC18200150

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BPS Bioscience

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Mfr.No.	78533
Description	Recombinant clonal CHO cell line stably expressing full length human claudin 18.2 (claudin18 isoform 2, CLDN18.2, gene accession number NM_001002026.3). The stable clonal cell line was selected for high levels of claudin 18.2 expression compared to the parental CHO-K1 cell line. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as Each vial contains 2 x 10⁶ cells in 1 ml of cell freezing medium (Biohippo #79796)
Background	Claudins are integral membrane proteins and components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin-18.1, which is found primarily in the lung, and claudin-18.2, which is expressed exclusively in the stomach. Claudin-18.2 is highly expressed in gastric and pancreatic adenocarcinoma, located in the outer cell membrane, and involved in tumor development and progression. In addition, it has exposed extracellular loops and is available for monoclonal antibody binding. These biological characteristics suggest that it is an ideal target for therapy and have led to the further development of monoclonal antibodies against claudin 18.2, such as Zolbetuximab.
Application	Test antibodies against claudin 18.2Screen inhibitors or neutralizing antibodies against claudin 18.2
Host Cell	CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200150	78533	2 vials	$7865		Add to Cart

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