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Claudin-18 Isoform 1 CHO Cell Line

SKU : BHC18200119

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Mfr.No.	78361
Description	Recombinant clonal CHO cell line stably expressing full-length human claudin 18.1 (claudin 18 isoform 1, CLDN18, gene accession number NM_016369.4). The stable clonal cell line was selected for high levels of claudin 18.1 expression compared to the parental CHO-K1 cell line. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as Each vial contains 2 x 10⁶ cells in 1 ml of cell freezing medium (Biohippo, #79796)
Background	Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin 18.1, which is found primarily in the lung, and claudin 18.2, which is expressed exclusively in the stomach. In claudin 18-deficient studies, claudin 18.1 was identified as a regulator of normal lung homeostasis as its deficiency promoted the proliferative state of malignant cells found in lung adenocarcinomas.¹ Therefore, claudin-18.1 may be a potential therapeutic target in cancer.¹
Application	Test antibodies against claudin 18.1 Screen inhibitors or neutralizing antibodies against claudin 18.1
Host Cell	CHO
Uniprot	P56856
Synonyms	CLDN18, UNQ778, PRO1572
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected]. Warning: Avoid freeze/thaw cycles.

Storage Stability	Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long-term storage.

Reference	Kyuno D., Takasawa A., Kikuchi S., Takemasa I., Osanai M., Kojima T. Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells. Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1863, Issue 3, 2021, 183503

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200119	78361	2 vials	$7865		Add to Cart

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